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KMID : 0368019890120030237
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Journal of Soonchunhyang University
1989 Volume.12 No. 3 p.237 ~ p.241
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Protective Effects of TIFA on CCl₄ induced Hepatotoxicity in Rats
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권준택/Kwon, J.T.
이종화/최규횽/조병헌/김종배/김유재/차영덕/Lee, J.H./Choi, K.H./Kim, J.B./Kim, Y.J./Cha, Y.D./Kim, C.S.
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Abstract
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Trithioformaldehyde(TTFA) is a cyclic aliphatic compound containing three sulfur atoms. TTFA was synthetized from formalin and hydrogen sulfide in our Lab.. Pharmacological effects of TTFA were clarified in our Lab.: antifungal effects, and radiation protective effect in mice. In this experiment, the protective effect of TTFA on CCI_(4) induced hepatotoxicity in rats was evaluated histopathologically. Groups consist of net control, administered with CCI_(4) only and TTFA pretreatment. CCI_(4)(1㎖/㎏) was given i.p. as a 50%(V / V) solution in olive oil. TTFA(300㎎ / ㎏) suspended in 5% arabia gum was geven i.p. 24hrs and 20min before CCI_(4) administration. The rats that received CCI_(4) were sacreficed 24hrs later. In pathological finding, massive fatty change with necrosis in the centrilobular area is found in CCI_(4) only treated group. In TTFA pretreated group, a slightly necreotic change in the midzone is noted. Remarkable reductions in hepatic glycogen were observed in CCI_(4) only administration. TTFA prevented them from disappearing.
These results show that TTFA has a significantly protective effects against CCI_(4) induced hepatotoxicity.
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